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INDONESIA
Indonesian Journal of Cancer
Published by Rumah Sakit Kanker Dharmais (Pusat Kanker Nasional)
ISSN : 19783744     EISSN : 23556811     DOI : -
Core Subject : Health,
Health Professions
The Indonesian Journal of Cancer (official journal of the Dharmais Cancer Center Hospital) is a peer-reviewed, quarterly, open access journal. Submissions are reviewed under a broad scope of topics relevant to experimental and clinical cancer research. The journal publishes original research articles, case reports, systematic literature reviews, and letters to the editor under the following categories: Cancer prevention, diagnosis, surgery, systemic therapy, radiotherapy, paliative therapy, and molecular biology.
Arjuna Subject : -
Articles 7 Documents
 1 
Search results for , issue " Vol 10, No 4 (2016): October - December 2016" : 7 Documents clear
Unusual Metastases of Hepatocellular Carcinoma to the Heart KURNIAWAN, ANDREE; LUGITO, NATA PRATAMA HARDJO
Indonesian Journal of Cancer Vol 10, No 4 (2016): October - December 2016
Publisher : Indonesian Journal of Cancer

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Abstract

ABSTRACTHepatocellular carcinoma (HCC) is the sixth most prevalent cancer worldwide. Metastasis of HCC to the heart is rare with prevalence on autopsy of less than 6%. There is still limited study evaluated the metastasis of hepatocellular carcinoma to the heart. The aim of this study is to know the prevalence and characteristic of metastasis of HCC to theheart in Indonesia. This retrospective study was conducted in secondary referral hospital in Tangerang county, Indonesia. We evaluated from medical record included baseline characteristic, survival and treatment of HCC and echocardiogram data for diagnosing metastasis to the heart from 2013-2015. There were 5 HCC patients recorded in thelast 3 years. All patients were male with median age 56(53-61) years old. Four patients were diagnosed using transthoracic echocardiograph and the rest using multi sliced CT scan. All patients were having continuous thrombus from inferior cava vein until right atrial. For the conclusion Hepatocellular carcinoma were reported as the cause ofintra-heart metastases in Indonesia. All patients were in late stage.ABSTRAKKarsinoma hepatoselular adalah kanker keenam terbanyak di seluruh dunia. Metastasis karsinoma hepatoselular ke jantung jarang, prevalensi yang ditemukan pada otopsi kurang dari 6 persen. Masih amat jarang studi yang mengevaluasi metastasis karsinoma hepatoselular ke jantung. Tujuan dari studi ini adalah ingin mengetahui prevalensi dankarakteristik metastasis karsinoma hepatoselular ke Jantung di Indonesia. Studi retrospektif ini dilakukan di rumah sakit rujukan tipe B di daerah Tangerang, Indonesia. Kami mengevaluasi dari rekam medis, meliputi karaktersitik dasar, kesintasan, dan terapi karsinoma hepatoselular; serta data ekokardiografi untuk mendiagnosis metastasis ke jantung dari 2013-2015. Terdapat 5 pasien hepatoselular karsinoma pada 3 tahun terakhir. Semua pasien laki-laki dengan usia median 56 (53-61) tahun. Empat pasien terdiagnosis menggunakan ekokardiografi trans torakal dan sisanya menggunakan CT scan. Semua pasien memiliki trombus kontinu dari vena cava inferior hingga atrium kanan. Sebagai simpulan, karsinoma hepatoselular dilaporkan sebagai penyebab metastasis ke jantung di Indonesia. Semua pasien datang pada stadium lanjut.
Mutasi EGFR pada Non-Small Cell Lung Cancer di Rumah Sakit Kanker “Dharmais” SARI, LENNY; PURWANTO, PURWANTO
Indonesian Journal of Cancer Vol 10, No 4 (2016): October - December 2016
Publisher : Indonesian Journal of Cancer

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Abstract

ABSTRACTThis descriptive study illustrated the proportion of EGFR mutation in non-small cell lung cancer (NSCLC) at “Dharmais” National Cancer Hospital. Examination of EGFR mutation started in 2015, 196 data was collected and 68 data being analyses. Fixed Formalin Paraffin Embedded (FFPE) processed by cobas® 4800 real time polymerase chain reaction. The results shown 34% patients NSCLC with EGFR mutation and all of them was single mutation. EGFR mutation happens in Exon 21 L858R 10 cases (44 %), Exon 19del 12 cases (52 %) and the type of Exon 20 S768I 1 case (4 %). This study found a high proportion of EGFR mutation.ABSTRAKStudi deskriptif ini menggambarkan proporsi mutasi Epidermal Growth Factor Receptor (EGFR) pada pasien dengan kanker paru di Rumah Sakit Kanker “Dharmais”. Telah terkumpul 196 data, tetapi terdapat 68 data yang telah selesai dilakukan pemeriksaan mutasi EGFR. Mutasi EGFR diperiksa menggunakan Formalin-Fixed Paraffin-Embedded (FFPE) dengan teknologi cobas® 4800 real-time polymerase chain reaction. Ditemukan 34% pasien dengan mutasi EGFR. Pada kelompok tersebut hanya ditemukan single mutation. Mutasi EGFR terjadi pada Exon 21 L858R sebanyak 10 kasus (44%), Exon 19del 12 kasus (52%), dan tipe Exon 20 S768I sebanyak 1 kasus (4%). Studi ini masih berlangsung dan diharapkan dapat memberikan gambaran yang lebih komprehensif tentang mutasi EGFR pada kanker paru.
Stereotactic Radiosurgery in Recurrent Brain Metastases After Prior Radiosurgery: A Case Report and Review of Literature KODRAT, HENRY; NOVIRIANTHY, RIMA
Indonesian Journal of Cancer Vol 10, No 4 (2016): October - December 2016
Publisher : Indonesian Journal of Cancer

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Abstract

ABSTRACTPreviously, all brain metastasis has been treated with whole brain radiotherapy and the survival is poor. Recently, the development of stereotactic radiosurgery (SRS) provides comparable efficacy with low toxicity, and in several cases have a better survival compared to historical data. We conducted a case review in brain metastasis, which has been treated with SRS previously and experienced distant brain recurrence, then re-treated with SRS.ABSTRAKDahulu, semua metastasis otak ditangani dengan modalitas radiasi seluruh otak dan memiliki kesintasan yang tidak terlalu baik. Saat ini berkembang modalitas stereotactic radiosurgery (SRS). SRS memberikan efektivitas yang sebanding dengan toksisitas yang rendah dan pada beberapa kasus memiliki kesintasan yang lebih baik dibandingkandata sebelumnya. Berikut adalah tinjauan kasus metastasis otak dengan penanganan SRS sebelumnya dan mengalami kekambuhan di lokasi lain pada otak, kemudian ditatalaksana ulang dengan SRS.
Identifikasi Isolat Antikanker Spons Hyrtios Erecta SWANTARA, I MADE DIRA; RITA, WIWIK SUSANAH; HERNINDYA, ANISA
Indonesian Journal of Cancer Vol 10, No 4 (2016): October - December 2016
Publisher : Indonesian Journal of Cancer

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Abstract

ABSTRACTIsolation, anticancer activity test, and identification of the toxic isolate from ethanol extract of the sponge Hyrtios erecta taken from Pari Island beach (Jakarta) has conducted. Extraction of the sponges was carried out by 70% ethanol at room temperature. Partition and purification of the compounds were done by column chromatography with the stationary phase of silica gel and the mobile phase of n-hexane-chloroform (2:8). Toxicity screening test was done based on Bhrine Shrimp Lethality Test (BSLT). In vitro anticancer activity test of the isolate was carried out using HeLa cell line. Identification of the compounds was performed by Gas chromatography-mass spectroscopy (GC-MS). Based on the results, it was found that the toxic isolate of H. erecta sponges has anticancer activity with IC50 of 30,497 ppm. Four compounds was detected from the anticancer isolate i.e: 4-nonylphenol; dibutyl phthalate; hexanedioic acid bis(2- ethylhexyl) ester; and cholesterol.ABSTRAKTelah dilakukan isolasi, uji aktivitas antikanker, dan identifikasi isolat toksik yang berasal dari ekstrak etanol spons Hyrtios erecta yang diambil dari perairan Pulau Pari (Jakarta). Ekstraksi dilakukan dengan cara maserasi menggunakan etanol 70% pada temperatur kamar. Pemisahan dan pemurnian komponen menggunakan kromatografi kolom denganfase diam silikagel dan fase gerak n-heksana-kloroform (2:8). Skrining toksisitas dilakukan dengan metode Bhrine Shrimp Lethality Test (BSLT). Uji antikanker secara in vitro isolat toksik tersebut menggunakan sel HeLa. Senyawanya diidentifikasi menggunakan Gas chromatography-mass spectroscopy (GC-MS). Berdasarkan hasil penelitian ini diperoleh bahwa isolat toksik spons H. erecta bersifat antikanker dengan IC50 sebesar 30,497 ppm. Pada isolat antikanker tersebut terdeteksi empat senyawa, yaitu 4-nonylphenol; dibutil phtalat; ester heksadioat bis(2-etilheksil); dankolesterol.
Identifikasi Isolat Antikanker Spons Hyrtios Erecta SWANTARA, I MADE DIRA; RITA, WIWIK SUSANAH; HERNINDYA, ANISA
Indonesian Journal of Cancer Vol 10, No 4 (2016): October - December 2016
Publisher : Indonesian Journal of Cancer

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (535.135 KB)

Abstract

ABSTRACTIsolation, anticancer activity test, and identification of the toxic isolate from ethanol extract of the sponge Hyrtios erecta taken from Pari Island beach (Jakarta) has conducted. Extraction of the sponges was carried out by 70% ethanol at room temperature. Partition and purification of the compounds were done by column chromatography with the stationary phase of silica gel and the mobile phase of n-hexane-chloroform (2:8). Toxicity screening test was done based on BhrineShrimp Lethality Test (BSLT). In vitro anticancer activity test of the isolate was carried out using HeLa cell line. Identification of the compounds was performed by Gas chromatography-mass spectroscopy (GC-MS). Based on theresults, it was found that the toxic isolate of H. erecta sponges has anticancer activity with IC50 of 30,497 ppm. Four compounds was detected from the anticancer isolate i.e: 4-nonylphenol; dibutyl phthalate; hexanedioic acid bis(2-ethylhexyl) ester; and cholesterol. ABSTRAKTelah dilakukan isolasi, uji aktivitas antikanker, dan identifikasi isolat toksik yang berasal dari ekstrak etanol spons Hyrtios erecta yang diambil dari perairan Pulau Pari (Jakarta). Ekstraksi dilakukan dengan cara maserasi menggunakan etanol 70% pada temperatur kamar. Pemisahan dan pemurnian komponen menggunakan kromatografi kolom dengan fase diam silikagel dan fase gerak n-heksana-kloroform (2:8). Skrining toksisitas dilakukan dengan metode Bhrine Shrimp Lethality Test (BSLT). Uji antikanker secara in vitro isolat toksik tersebut menggunakan sel HeLa. Senyawanya diidentifikasi menggunakan Gas chromatography-mass spectroscopy (GC-MS). Berdasarkan hasil penelitian ini diperoleh bahwa isolat toksik spons H. erecta bersifat antikanker dengan IC50 sebesar 30,497 ppm. Pada isolat antikankertersebut terdeteksi empat senyawa, yaitu 4-nonylphenol; dibutil phtalat; ester heksadioat bis(2-etilheksil); dan kolesterol.
Mutasi EGFR pada Non-Small Cell Lung Cancer di Rumah Sakit Kanker “Dharmais” SARI, LENNY; PURWANTO, PURWANTO
Indonesian Journal of Cancer Vol 10, No 4 (2016): October - December 2016
Publisher : Indonesian Journal of Cancer

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (528.765 KB)

Abstract

ABSTRACTThis descriptive study illustrated the proportion of EGFR mutation in non-small cell lung cancer (NSCLC) at “Dharmais” National Cancer Hospital. Examination of EGFR mutation started in 2015, 196 data was collected and 68 data being analyses. Fixed Formalin Paraffin Embedded (FFPE) processed by cobas® 4800 real time polymerase chain reaction. The results shown 34% patients NSCLC with EGFR mutation and all of them was single mutation. EGFR mutation happens in Exon 21 L858R 10 cases (44 %), Exon 19del 12 cases (52 %) and the type of Exon 20 S768I 1 case (4 %). This study found a high proportion of EGFR mutation.ABSTRAKStudi deskriptif ini menggambarkan proporsi mutasi Epidermal Growth Factor Receptor (EGFR) pada pasien dengan kanker paru di Rumah Sakit Kanker “Dharmais”. Telah terkumpul 196 data, tetapi terdapat 68 data yang telah selesai dilakukan pemeriksaan mutasi EGFR. Mutasi EGFR diperiksa menggunakan Formalin-Fixed Paraffin-Embedded (FFPE)dengan teknologi cobas® 4800 real-time polymerase chain reaction. Ditemukan 34% pasien dengan mutasi EGFR. Pada kelompok tersebut hanya ditemukan single mutation. Mutasi EGFR terjadi pada Exon 21 L858R sebanyak 10 kasus (44%), Exon 19del 12 kasus (52%), dan tipe Exon 20 S768I sebanyak 1 kasus (4%). Studi ini masih berlangsung dan diharapkan dapat memberikan gambaran yang lebih komprehensif tentang mutasi EGFR pada kanker paru.
Analisis Ketahanan Hidup Tumor Testis Sel Germinal di RS Sardjito Periode 2007-2013 Prayoga, Denny Achmad; Danarto, HR
Indonesian Journal of Cancer Vol 10, No 4 (2016): October - December 2016
Publisher : Indonesian Journal of Cancer

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Abstract

ABSTRACTObjective: To know survival of germ cell testicle tumor at Sardjito hospital who had chemotherapy or radiotherapy and its factor which influenced their survivalMethod: From year 2007 until 2013, we collected patients with germ cell testicle tumor at Sardjito hospital who had chemotherapy or radiotherapy. The clinical factor that studied were age, histopathology findings, the TNMS staging, clinical staging, therapy and survival status. We evaluate their survival up to five years after therapy. Correlation between survival status with age, histopathology findings, the TNMS staging, clinical staging,therapy and prognosis were analyzed using Fisher Exact Test. The Kaplan Meier survival analysis was used to calculate survival of germ cell testicle tumor. Result: There are 23 patient of germ cell testicle tumor whom 21 patients had chemotherapy and 2 patients had radiotherapy. There are no correlation between survival status with age, histopathology findings, the TNMS staging, clinical staging, therapy and prognosis (p>0.05). Based on Kaplan Meier survival analysis, their survival were better on age < 30 years old (p=0.534), seminoma type (p=0.860), had chemotherapy (p=0.599), T3 (p=0.031), Nx (p=0.394), Mx (p=0.781), 51 staging (p=0.623) dan 3rdstadium (p=0.732). Based on risk classification, survival of seminoma with intermediate prognosis were better than seminoma with good prognosis (p=0.631) whereas survival of non seminoma with good prognosis were higher than non seminoma with intermediate or poor prognosis (p=0.014). Conclusion: Germ cell testicle tumor at Sardjito hospital had dominant of seminoma type and had already developed into advanced staged with chemoterapy as therapy. Survival of germ cell testicle tumor were lower than other country. T3 staging and non seminoma with good prognosis could be prognostic factor of germ cell testicle tumor at Sardjito hospital.ABSTRAKObjektif: Untuk mengetahui gambaran ketahanan hidup pasien tumor testis jenis sel germinal di RS Sardjito yang dilakukan kemoterapi maupun radioterapi serta faktor-faktor yang mempengaruhi ketahanan hidup tumor testis jenis sel germinal Bahan dan cara: Dari tahun 2007-2013, dilakukan pendataan pasien dengan tumor testis jenis sel germinal di RS Sardjito baik yang dilakukan kemoterapi maupun radioterapi. Data yang dipelajari adalah usia, jenis histopatologi, stadium T, N, M, S, stadium klinis dan status ketahanan hidup. Dilakukan evaluasi ketahanan hidup hingga 5 tahun post terapi. Dilakukan analisa bivariat menggunakan tes Fisher untuk menilai hubungan antara ketahanan hidup dengan faktor-faktor seperti usia, jenis histopatologi, stadium T, N, M, S, stadium klinis, jenis terapi dan prognosis. Digunakan kurva Kaplan Meier untuk menilai gambaran ketahanan hidup pasien tumor testis sel germinal. Hasil: Ada 23 pasien tumor testis jenis sel germinal di RS Sardjito periode 2007-2013 dimana 21 pasien mendapatkan kemoterapi dan 2 pasien mendapatkan radioterapi. Tidak dijumpai hubungan bermakna antara ketahanan hidup pasien tumor buli jenis sel germinal dengan usia, jenis histopatologi, stadium T, N, M, S, stadium klinis dan prognosis(p>0.05). Berdasarkan kurva Kaplan Meier diketahui ketahanan hidup tumor testis sel germinal lebih baik pada usia < 30 tahun (p=0.534), jenis non seminoma (p=0.860), stadium T3 (p=0.031), Nx (p=0.394), Mx (p=0.781), S1 (p=0.623) dan stadium 3 (p=0.732). Berdasarkan klasifikasi resiko, ketahanan hidup tumor testis jenis seminoma dengan prognosis sedang lebih baik dibandingkan tumor testis jenis seminoma dengan prognosis baik (p=0.631) sedangkan ketahanan hidup jenis non seminoma dengan prognosis baik lebih tinggi dibandingkan tumor testis jenis non seminoma dengan prognosis sedang dan buruk (p=0.014). Kesimpulan: Tumor testis sel germinal di RS Sardjito mayoritas jenis seminoma dan sudah dalam stadium lanjut dengan kemoterapi sebagai sarana terapi. Angka ketahanan hidup tumor testis jenis sel germinallebih rendah dibandingkan negara lain. Stadium T3 dan grup non seminoma prognosis baik dapat dijadikan faktor prognostik ketahanan hidup tumor testis sel germinal di RS Sardjito.

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